pkdl incidence compared sda Search Results


pkdl incidence compared sda  (Gilead Sciences)
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Gilead Sciences pkdl incidence compared sda
Hypothetical relationship between decreasing parasite load and increasing immunity. In case of downgrading of the immune response (red arrow), <t>PKDL</t> is likely to result in a macular rash first with stronger immune response ( A , higher CMI*, scanty parasites) than a polymorphic or papulonodular rash ( B , lower CMI*, higher number of parasites). In case of upgrading of the immune response the opposite would occur. * CMI cell-mediated immunity.
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Hypothetical relationship between decreasing parasite load and increasing immunity. In case of downgrading of the immune response (red arrow), PKDL is likely to result in a macular rash first with stronger immune response ( A , higher CMI*, scanty parasites) than a polymorphic or papulonodular rash ( B , lower CMI*, higher number of parasites). In case of upgrading of the immune response the opposite would occur. * CMI cell-mediated immunity.

Journal: PLOS Neglected Tropical Diseases

Article Title: Risk factors for post-kala-azar dermal leishmaniasis (PKDL): Challenges in understanding pathophysiology

doi: 10.1371/journal.pntd.0013952

Figure Lengend Snippet: Hypothetical relationship between decreasing parasite load and increasing immunity. In case of downgrading of the immune response (red arrow), PKDL is likely to result in a macular rash first with stronger immune response ( A , higher CMI*, scanty parasites) than a polymorphic or papulonodular rash ( B , lower CMI*, higher number of parasites). In case of upgrading of the immune response the opposite would occur. * CMI cell-mediated immunity.

Article Snippet: The MF + PM combination had a higher PKDL incidence compared SDA (single dose AmBisome); the risk of PKDL was higher in children <12 years and females.

Techniques: